The film is framed around interviews with a number of members of the transhumanist, bioethics, disability, and robotics communities, such as Rodney Brooks, James Hughes, and Marcy Darnovsky. But it focuses primarily on three figures, each of whom is disabled: John Hockenberry, an accomplished journalist and a Distinguished Fellow of the M.I.T. Media Lab; Gregor Wolbring, a biochemist and bioethicist at the University of Calgary; and Patty Berne, a disability and LGBT activist.